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Chronic hypersensitivity pneumonitis

Authors Pereira C, Gimenez A, Kuranishi L, Storrer K

Received 26 September 2015

Accepted for publication 19 January 2016

Published 21 September 2016 Volume 2016:9 Pages 171—181

DOI https://doi.org/10.2147/JAA.S81540

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Saeed Kolahian

Peer reviewer comments 2

Editor who approved publication: Dr Amrita Dosanjh


Carlos AC Pereira,1 Andréa Gimenez,2 Lilian Kuranishi,2 Karin Storrer 2

1Interstitial Lung Diseases Program, 2Pulmonology Postgraduate, Federal University of São Paulo, São Paulo, Brazil

Abstract: Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies. Treatment options are limited, but lung transplantation results in greater survival in comparison to idiopathic pulmonary fibrosis. Randomized trials with new antifibrotic agents are necessary.

Keywords: interstitial lung diseases, extrinsic allergic alveolitis, diffuse lung disease, lung immune response, HRCT, farmers lung

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