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Characteristics of diabetic macular edema on optical coherence tomography may change over time or after treatment

Authors Sheu SJ, Lee YY, Horng YH, Lin HS, Lai WY, Tsen CL

Received 14 May 2018

Accepted for publication 11 July 2018

Published 26 September 2018 Volume 2018:12 Pages 1887—1893

DOI https://doi.org/10.2147/OPTH.S173956

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Shwu-Jiuan Sheu,1,2 Ying-Yen Lee,1 Yu-Harn Horng,1 Huey-Shyan Lin,3 Wei-Yu Lai,1 Chui-Lien Tsen1

1Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; 2Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Department of Health-Business Administration, Fooyin University, Kaohsiung, Taiwan

Purpose: To investigate optical coherence tomography (OCT) characteristics in diabetic macular edema (DME) over time and after treatment.
Patients and methods: OCT morphological features in DME eyes treated with ranibizumab with at least 1 year of follow-up were retrospectively analyzed.
Results: Thirty-five eyes were included. From baseline to Month 12, mean visual gain was 7.2±13.6 letters and mean central retinal thickness reduction was 61.9±121.8 µm. Fovea-involving ellipsoid zone (EZ) disruption was significantly associated with final vision of <70 letters. Subretinal fluid at baseline was present only in eyes naïve to previous intravitreal pharmacotherapy and was related to better visual gain and fewer injections. Treatment-naïve eyes had shorter DME duration and less EZ damage.
Conclusion: DME characteristics on OCT may change over time or after treatment. Subretinal fluid may be associated with earlier change and less EZ damage in DME.

Keywords:
diabetic macular edema, optical coherence tomography, OCT, subretinal fluid, SRF, vascular endothelial growth factor, VEGF

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