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Cell adhesion molecules in Alzheimer's disease

Authors Wennström, Nielsen H

Received 1 February 2012

Accepted for publication 24 March 2012

Published 5 July 2012 Volume 2012:2 Pages 65—77


Review by Single-blind

Peer reviewer comments 3

Malin Wennström, Henrietta M Nielsen
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

Abstract: Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-ß (Aß) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer's disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.

Keywords: cell adhesion molecules, Alzheimer's disease, neuroinflammation, plasticity, amyloid-beta, vascular changes

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