Cell adhesion molecules and exercise
Received 5 April 2018
Accepted for publication 21 May 2018
Published 24 July 2018 Volume 2018:11 Pages 297—306
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Andrew Yee
Peer reviewer comments 3
Editor who approved publication: Dr Ning Quan
Yunsuk Koh,1 Jinkyung Park2
1Department of Health, Human Performance, and Recreation, Baylor University, Waco, TX, USA; 2Department of Kinesiology, George Mason University, Manassas, VA, USA
Background: An extensive systematic review was undertaken in the current literature in order to explore the role of different types and intensities of exercise in cell adhesion molecules (CAMs), one of the markers of vascular inflammation, endothelial dysfunction, and atherosclerosis.
Methods: Twenty-eight qualifying studies were extensively reviewed to examine the effects of different intensities (low-to-moderate vs. high) and types (aerobic vs. resistance) of exercise on intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectins.
Results: Low-to-moderate intensity aerobic exercise favorably decreased CAMs in a variety of subject populations, while CAMs momentarily increased immediately following high-intensity aerobic exercise, which then returned to the pre-exercise level within several hours post-exercise. Resistance exercise, regardless of its intensity, did not significantly influence CAMs.
Conclusion: It is evident that the responses of CAMs are dependent upon the type and intensity of exercise performed. The most common, favorable outcome was a decrease in CAMs following low-to-moderate intensity aerobic exercise, while high-intensity aerobic exercise showed a short-lived, momentary increase in CAMs, which returned to the pre-exercise level within a few hours post-exercise. Resistance exercise, regardless of its intensity, neither significantly increased nor decreased CAMs. Future studies should focus more on the role of exercise in both soluble and membrane-bound CAMs as well as proinflammatory cytokines related to atherosclerosis in order to develop specific exercise programing that can effectively improve vascular inflammation and endothelial health.
Keywords: ICAM-1, VCAM-1, endothelial dysfunction, inflammation, cardiovascular diseases, atherosclerosis
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]