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Bilateral lower extremity hyperkeratotic plaques: a case report of ichthyosis vulgaris

Authors Leight H, Zinn Z, Jalali O

Received 4 June 2015

Accepted for publication 30 July 2015

Published 15 September 2015 Volume 2015:8 Pages 485—488


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Hayley Leight, Zachary Zinn, Omid Jalali

Department of Dermatology, West Virginia University, Morgantown, WV, USA

Abstract: Here, we report a case of a middle-aged woman presenting with severe, long-standing, hyperkeratotic plaques of the lower extremities unrelieved by over-the-counter medications. Initial history and clinical findings were suggestive of an inherited ichthyosis. Ichthyoses are genetic disorders characterized by dry scaly skin and altered skin-barrier function. A diagnosis of ichthyosis vulgaris was confirmed by histopathology. Etiology, prevalence, and treatment options are discussed.

Keywords: filaggrin gene, FLG, profilaggrin, keratohyalin granules, hyperkeratosis

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