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Balanced discussion of second-generation antihistamines' data

Authors Boev R, Bentz JWG

Received 8 October 2016

Accepted for publication 27 October 2016

Published 24 November 2016 Volume 2016:12 Pages 1777—1781

DOI https://doi.org/10.2147/TCRM.S124148

Checked for plagiarism Yes

Editor who approved publication: Professor Garry Walsh

Rossen Boev,1 Jürgen WG Bentz2

1UCB Pharma, Bulle, Switzerland; 2UCB Pharma, Brussels, Belgium
 
It is with interest that we read the paper “Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine” by Wang et al1, in which the authors provide insights into the burden of allergic diseases in the Asia-Pacific region. Unfortunately, we found that the review provides some unsubstantiated information, incorrect statements, and/or data inconsistencies as listed below.
The abstract states that bilastine “has very low potential for drug–drug interactions”; however, the drug label lists interactions with ketoconazole, erythromycin, diltiazem, and other intestinal efflux transporters, leading to 2–3-fold increases in drug maximum serum concentration and area under the curve2. Also, food interactions decrease bilastine’s bioavailability by 30%, and the label recommendation is that it is taken 1 hour before or 2 hours after intake of food or fruit juice2
View the original article by Wang et al.

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