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Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression

Authors Zhou H, Hua L, Jiang H, Dai Z, Han Y, Lin P, Wang H, Lu Q, Yao Z

Received 10 November 2019

Accepted for publication 30 December 2019

Published 21 January 2020 Volume 2020:16 Pages 235—247

DOI https://doi.org/10.2147/NDT.S238044

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Yuping Ning


Hongliang Zhou, 1 Lingling Hua, 1 Haiteng Jiang, 2 Zongpeng Dai, 2 Yinglin Han, 1 Pinhua Lin, 1 Haofei Wang, 1 Qing Lu, 2, 3 Zhijian Yao 1, 4

1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China; 3Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing 210096, People’s Republic of China; 4Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing 210093, People’s Republic of China

Correspondence: Zhijian Yao
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Tel +8625 8229600
Fax +8625 82296000
Email zjyao@njmu.edu.cn
Qing Lu
School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China
Tel/Fax +8625 83792349
Email luq@seu.edu.cn

Objective: To investigate the mechanism of interactions between autonomic nervous system (ANS) and cognitive function in Major depression (MD) with Magnetoencephalography (MEG) measurements.
Methods: Participants with MD (n = 20), and Health controls (HCs, n = 18) were completed MEG measurements during the performance of a go/no-go task. Heart rate variability (HRV) indices (SDANN, and RMSSD) were derived from the raw MEG data. The correlation analysis of the HRV and functional connectivities in different brain regions was conducted by Pearson’s r in two groups.
Results: The go/no-go task performances of HCs were better than MD patients; HRV indices were lower in the MD group. Under the no-go task, a brain MEG functional connectivity analysis based on the seed regions of the orbitofrontal cortex (OFC) displayed increased functional inter-region connectivity networks of OFC in MD group. HRV indices were correlated with different functional inter-region connectivity networks of OFC in two groups, respectively.
Conclusion: ANS is related to inhibitory and control function through functional inter-region connectivity networks of OFC in MD. These findings have important implications for the understanding pathophysiology of MD, and MEG may provide an image-guided tool for interventions.

Keywords: major depression, magnetoencephalography, heart rate variability, functional connectivity, the orbitofrontal cortex

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