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Association of two FOXP3 polymorphisms with breast cancer susceptibility in Chinese Han women

Authors Tian T, Wang M, Zheng Y, Yang T, Zhu W, Li H, Lin S, Liu K, Xu P, Deng Y, Zhou L, Dai Z

Received 29 November 2017

Accepted for publication 13 February 2018

Published 26 April 2018 Volume 2018:10 Pages 867—872

DOI https://doi.org/10.2147/CMAR.S158433

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Antonella D'Anneo


Tian Tian,1,* Meng Wang,1,* Yi Zheng,1,* Tielin Yang,2 Wenge Zhu,3 Hongtao Li,4 Shuai Lin,1 Kang Liu,1 Peng Xu,1 Yujiao Deng,1 Linghui Zhou,1 Zhijun Dai1

1Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China; 2School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, People’s Republic of China; 3Department of Biochemistry and Molecular Medicine, The George Washington University Medical School, Washington, DC, USA; 4Department of Breast Head and Neck Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumchi, People’s Republic of China

*These authors contributed equally to this work

Background: Forkhead box P3 (FOXP3) is a key gene in the immune system which also plays a role in tumor development. This study aims to explore the association of two FOXP3 polymorphisms (rs3761548 and rs3761549) with susceptibility to breast cancer (BC).
Method: A case–control study was conducted, involving 560 patients and 583 healthy individuals from the Chinese Han population. The genotypes of FOXP3 polymorphisms were detected using the Sequenom MassARRAY method. The association between FOXP3 polymorphisms and BC risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (95% CIs) under six genetic models. False-positive report probability was utilized to examine whether the significant findings were noteworthy.
Results: We observed that rs3761548 was associated with a higher BC risk in heterozygous, dominant, overdominant, and allele genetic models (CA vs CC: OR =1.32, P=0.031; CA/AA vs CC: OR =1.32, P=0.023; CA vs CC/AA: OR =1.29, P=0.042; A vs C: OR =1.26, P=0.029), whereas no significant association was found between rs3761549 and BC risk. In addition, CA, CA/AA genotype, and A allele of rs3761548 were related to larger tumor size, and the A allele was also correlated with a positive status of Her-2 in BC patients.
Conclusion: Our study suggests that FOXP3 polymorphism rs3761548 is associated with BC susceptibility in the Chinese and may be involved in tumor progression. Future studies are needed to confirm the results in a larger population with more races.

Keywords: forkhead box P3, polymorphism, breast cancer, risk

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