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Association between the IL-6 gene polymorphism and tuberculosis risk: a meta-analysis

Authors Wang H, Pang C, Zeng N, Wan C, Shen Y, Wen F

Received 19 June 2017

Accepted for publication 6 October 2017

Published 27 November 2017 Volume 2017:10 Pages 445—454


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink

Hao Wang,1,* Caishuang Pang,2,* Ni Zeng,1 Chun Wan,1 Yongchun Shen,1 Fuqiang Wen1

1Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, China; 2Chongqing Cancer Institute & Hospital & Cancer Center, Chongqing, China

*These authors contributed equally to this work

The gene polymorphism of interleukin-6 (IL-6) has been shown to be implicated in tuberculosis susceptibility in many studies, but with conflicting results. This study aimed to provide more accurate estimation of the relationship between IL-6 gene polymorphism and tuberculosis risk through a meta-analysis
Method: A literature search was performed in PubMed, EMBASE, and other databases. Data were retrieved, and pooled odds ratio (OR) with 95% CI were calculated. Statistical analyses were performed by using STATA 12.0.
Results: Twelve publications with 2635 cases and 3049 controls were included. The pooled analysis demonstrated significant evidence of association between IL-6 (-174G/C) and low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.693, 95% CI 0.581–0.826, p<0.001). Subgroup analysis got similar results for IL-6 (-174G/C) in Asians and Latinos, but the significance did not exist in Caucasians. IL-6 (-572C/G) polymorphism was also associated with low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.719, 95% CI 0.577–0.896, p=0.003). No publication bias was detected in either of the polymorphisms.
Conclusion: In summary, IL-6 -572 C/G polymorphism may be associated with a decreased risk of tuberculosis, and C allele is the protective factor against tuberculosis for IL-6 -174G/C among Asians and Latinos, but not in Caucasian population.

Keywords: interleukin-6, rs1800795, rs1800796, TB

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