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Anti-IL-10 antibody in systemic lupus erythematosus

Authors Uchida M, Ooka S, Goto Y, Suzuki K, Fujimoto H, Ishimori K, Matsushita H, Takakuwa Y, Kawahata K

Received 24 October 2018

Accepted for publication 27 December 2018

Published 26 March 2019 Volume 2019:11 Pages 61—65

DOI https://doi.org/10.2147/OARRR.S191953

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Chuan-Ju Liu


Marina Uchida, Seido Ooka, Yutaka Goto, Kanako Suzuki, Hisae Fujimoto, Kana Ishimori, Hiromi Matsushita, Yukiko Takakuwa, Kimito Kawahata

Division of Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan

Purpose: IL-10 is a cytokine known to inhibit inflammatory cytokines. To determine its role in the pathogenesis of systemic lupus erythematosus (SLE), the presence of anti-IL-10 antibody is required to be examined. Although antibodies against cytokines are known to be present in SLE, no studies have determined the role of IL-10, particularly in Japanese patients. We assayed anti-IL-10 antibody in SLE and examined the clinical significance.
Patients and methods: We performed a retrospective study of 80 Japanese patients with SLE. Sixteen scleroderma patients, 19 rheumatoid arthritis (RA) patients, 23 Behcet’s disease patients, and 23 healthy subjects were selected as control groups. Clinical information was abstracted from medical records. Anti-IL-10 antibody level was determined with an ELISA.
Results: With the cutoff established as serum absorbance +2 SDs (OD 0.729) in healthy subjects, we defined any sample above this cutoff as anti-IL-10 antibody-positive. Fourteen patients with SLE (17.5%) were found to be anti-IL-10 antibody positive. Absorbance was significantly higher in serum from patients with SLE and RA than in healthy individuals. In SLE, patients with low complement values were significantly more common in the antibody-positive group. Serum IgG levels were significantly higher in the antibody-positive group. In multivariable analysis, high level of serum IgG is associated with anti-IL-10 antibody positive.
Conclusion: The present study found that anti-IL-10 antibody is present in SLE and related to clinical parameters. These results suggest that the presence of anti-IL-10 antibody was associated with high level of serum IgG, but is not associated with disease activity in patients with SLE.

Keywords: anti-IL-10 antibody, IL-10, systemic lupus erythematosus, autoantibody


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