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Animal models of Parkinson's disease and their applications

Authors Park HJ, Zhao TT, Lee MK

Received 30 November 2015

Accepted for publication 24 February 2016

Published 12 July 2016 Volume 2016:6 Pages 73—82

DOI https://doi.org/10.2147/JPRLS.S85419

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Dr Peter Hedera


Hyun Jin Park, Ting Ting Zhao, Myung Koo Lee

Department of Pharmacy, Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea

Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder that occurs mainly due to the degeneration of dopaminergic neuronal cells in the substantia nigra. l-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective known therapy for PD. However, chronic L-DOPA administration results in a loss of drug efficacy and irreversible adverse effects, including L-DOPA-induced dyskinesia, affective disorders, and cognitive function disorders. To study the motor and non-motor symptomatic dysfunctions in PD, neurotoxin and genetic animal models of PD have been widely applied. However, these animal models do not exhibit all of the pathophysiological symptoms of PD. Regardless, neurotoxin rat and mouse models of PD have been commonly used in the development of bioactive components from natural herbal medicines. Here, the main animal models of PD and their applications have been introduced in order to aid the development of therapeutic and adjuvant agents.

Keywords:
Parkinson's disease, neurotoxin animal models, genetic animal models, adjuvant therapeutics

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