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An open-label pilot study to assess the effectiveness of krill oil with added vitamins and phytonutrients in the relief of symptoms of PMS

Authors Wakeman MP

Received 13 May 2013

Accepted for publication 24 July 2013

Published 27 September 2013 Volume 2013:5 Pages 17—25

DOI https://doi.org/10.2147/NDS.S48133

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Michael P Wakeman

School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands, UK

Abstract: An open-label pilot study over 4 months to evaluate the effectiveness of a compound formulation of ingredients, which individually have been demonstrated to be implicated in the pathogenesis of premenstrual syndrome to ameliorate the most troublesome symptoms of the condition. The supplement provided thiamine, riboflavin, pyridoxine, vitamin D, soy isoflavones, rosemary extract, and krill oil and was taken each day for the 3 months of the trial. Statistically significant effect was reported by the 29 women who completed the study in relief of anxiety, bloating, mood swings, breast tenderness, skin outbreaks, food cravings, fatigue, forgetfulness, insomnia, and headache after 3 months of treatment compared with baseline. This pilot study indicates the formulation to be effective, and a larger placebo-controlled trial is now planned.

Keywords: thiamine, riboflavin, pyridoxine, vitamin D, soy isoflavones, rosemary extract, premenstrual syndrome

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