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Advanced nanomaterials targeting hypoxia to enhance radiotherapy

Authors Li J, Shang W, Li Y, Fu S, Tian J, Lu L

Received 12 May 2018

Accepted for publication 9 August 2018

Published 1 October 2018 Volume 2018:13 Pages 5925—5936

DOI https://doi.org/10.2147/IJN.S173914

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Jia Li,1–3,* Wenting Shang,2,3,* Yong Li,1,* Sirui Fu,1–3 Jie Tian,2,3 Ligong Lu1

1Zhuhai Precision Medical Center, Zhuhai People’s Hospital, Jinan University, Zhuhai, China; 2CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; 3Beijing Key Laboratory of Molecular Imaging, Beijing, China

*These authors contributed equally to this work

Abstract: Hypoxia within solid tumors is often responsible for the failure of radiotherapy. The development of hypoxia-targeting nanomaterials – aimed at enhancing the effect of radiotherapy by electrical or heat effects and at modulating hypoxia in the tumor microenvironment – is a promising strategy to address this issue. We provide an overview of recently developed advanced materials that potentiate radiotherapy. First, we summarize novel materials for oxygen delivery or production to modify the tumor microenvironment, thus improving the effects of ionizing radiation. Second, we present new approaches for the design of high-Z element–based multifunctional nanoplatforms to enhance radiotherapy. Third, novel drug delivery systems for hypoxic regions and hypoxia-inducible factor-1–targeted therapies are discussed. Fourth, we establish the effectiveness of X-ray- or near-infrared–responsive nanoparticles for selectively triggering therapeutic effects under hypoxic conditions. Finally, this review emphasizes the importance of research in the field of nanomedicine focused on tumor hypoxia to improve clinical outcomes.

Keywords: radiotherapy, hypoxia, nanomaterials, hypoxia-inducible factor 1

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