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Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance

Authors Abdi SN, Ghotaslou R, Ganbarov K, Mobed A, Tanomand A, Yousefi M, Asgharzadeh M, Kafil HS

Received 21 August 2019

Accepted for publication 13 December 2019

Published 12 February 2020 Volume 2020:13 Pages 423—434


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Joachim Wink

Seyyed Naser Abdi, 1, 2 Reza Ghotaslou, 3 Khudaverdi Ganbarov, 4 Ahmad Mobed, 1 Asghar Tanomand, 5 Mehdi Yousefi, 3 Mohammad Asgharzadeh, 6 Hossein Samadi Kafil 1

1Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; 2Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; 3Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 4Department of Microbiology, Baku State University, Baku, Republic of Azerbaijan; 5Department of Basic Sciences, Maragheh University of Medical Sciences, Maragheh, Iran; 6Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence: Hossein Samadi Kafil Email

Abstract: Acinetobacter baumannii is a nosocomial pathogen and gram-negative coccobacillus that is responsible for opportunistic infections, pneumonia, and infections of the urinary tract, bloodstream, skin, and soft tissue. This bacterium poses a major public health problem due to inducing resistance to several drugs, isolates, multidrug treatment, and occasionally pan drugs. Drug resistance is not only a major concern caused by A. baumannii but also is considered as the main challenge in many other pathogens. Several factors such as the efflux pump are associated with antibiotic resistance, biofilm production, and genetic mutations. In this review, A. baumannii is introduced in then some of the practical works conducted on the existing efflux pump are reviewed. The importance of the efflux pump is considered in this paper in relation to the antibiotic resistance and mechanisms developed for the inhibition of these pumps as well.

Keywords: Acinetobacter baumannii, efflux pumps, antibiotic resistance, biofilm, transporters

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