A Randomized Pilot Clinical Assessment Of Three Skincare Regimens On Skin Conditions In Infants
Received 20 February 2019
Accepted for publication 10 October 2019
Published 16 December 2019 Volume 2019:12 Pages 895—909
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Yuanyuan Duan,1 Lin Ma,2 Carlos Galzote,3 Fan-Qi Kong,1 Chun-Ping Shen2
1Johnson & Johnson Asia Pacific Skin Testing Center, Minhang, Shanghai, People’s Republic of China; 2Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, MOE Key Laboratory of Major Diseases in Children, Beijing, People’s Republic of China; 3Johnson & Johnson International (Singapore) Pte. Ltd., Singapore, Singapore
Correspondence: Carlos Galzote
Johnson & Johnson International (Singapore) Pte. Ltd., Km 14 Edison Road, Bo. Ibayo, Paranaque City 1700, Philippines
Tel +632 368 8260
Fax +632 824 2329
Introduction: Few data are available on the comparison between the effects on infant skin of skin care products and those of water alone.
Patients and methods: In this single-center, evaluator-blind, parallel-group pilot study, healthy infants were randomized to near-daily washing for 12 weeks (starting in the summer and finishing in the winter months) with a mild liquid baby wash followed by use of baby lotion (wash+lotion), water followed by baby lotion (water+lotion), or water alone. Clinical and instrumental assessments of skin moisturization and barrier function were made.
Results: As expected the skin condition in all groups was affected by the change of the season. The skin of infants in all groups was mildly deteriorated (clinical grading) and with reduced moisture levels and increased barrier function. Instrumental measurements indicated that skin moisture and barrier function were better maintained in the wash+lotion and water+lotion groups than in the water-only group at week 12. Clinical assessment scores increased slightly over 12 weeks in all groups (P<0.05). At week 12, the wash+lotion group (n = 44) had significantly less change from baseline in overall skin condition and softness (lower scores) than did the water+lotion (n = 43) or water-only (n = 43) groups. The wash+lotion regimen maintained stable erythema and rash scores with lower mean values over time than in the other groups.
Conclusion: A regimen of a liquid baby wash and a baby skin lotion for 12 weeks resulted in less detrimental changes in instrumental and clinical measures of skin than using water and lotion or water alone.
Keywords: skin abnormalities, erythema, exanthema, emollients, infant
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