Back to Journals » Neuropsychiatric Disease and Treatment » Volume 11

A meta-analysis of lipid peroxidation markers in major depression

Authors Mazereeuw G, Herrmann N, Andreazza A, Khan M, Lanctôt KL

Received 5 June 2015

Accepted for publication 24 July 2015

Published 29 September 2015 Volume 2015:11 Pages 2479—2491

DOI https://doi.org/10.2147/NDT.S89922

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Graham Mazereeuw,1,2 Nathan Herrmann,1,3 Ana C Andreazza,2–4 Maisha M Khan,1 Krista L Lanctôt1–3

1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Department of Psychiatry, University of Toronto, 4Centre for Addiction and Mental Health, Toronto, ON, Canada

Background: Major depressive disorder (MDD) may be associated with oxidative damage to lipids, which can potentially affect mood-regulating pathways. This meta-analysis summarizes current knowledge regarding lipid peroxidation markers in clinical samples of MDD and the effects of antidepressant pharmacotherapy on those markers.
Methods: MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Collaboration were searched for original, peer-reviewed articles measuring markers of lipid peroxidation in patients with MDD and nondepressed healthy controls up to April 2015. Standardized mean differences (SMDs) were generated from random effects models summarizing mean (± standard deviations) concentrations of selected markers.
Results: Lipid peroxidation was greater in MDD than in controls (studies =17, N=857 MDD/782 control, SMD =0.83 [0.56–1.09], z=6.11, P<0.01, I2=84.0%) and was correlated with greater depressive symptom severity (B=0.05, df=8, P<0.01). Antidepressant treatment was associated with a reduction in lipid peroxidation in MDD patients (studies=5, N=222, SMD=0.71 [0.40–0.97], P<0.01; I2=42.5%).
Limitations: Lipid peroxidation markers were sampled from peripheral blood, included studies comparing MDD to controls were all cross-sectional, and only five antidepressant treatment studies were eligible for inclusion.
Conclusion: Increased lipid peroxidation was associated with MDD and may be normalized by antidepressants. Continued investigation of lipid peroxidation in MDD is warranted.

Keywords: antidepressant treatment, biomarker, malondialdehyde, depressive episode, reactive oxygen species, lipid peroxidation

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Serum low-density lipoprotein levels, statin use, and cognition in patients with coronary artery disease

Rej S, Saleem M, Herrmann N, Stefatos A, Rau A, Lanctôt KL

Neuropsychiatric Disease and Treatment 2016, 12:2913-2920

Published Date: 10 November 2016

Platelet activating factors are associated with depressive symptoms in coronary artery disease patients: a hypothesis-generating study

Mazereeuw G, Herrmann N, Xu H, Blanchard AP, Figeys D, Oh PI, Bennett SAL, Lanctôt KL

Neuropsychiatric Disease and Treatment 2015, 11:2309-2314

Published Date: 4 September 2015

Kynurenine and depressive symptoms in a poststroke population

Bensimon K, Herrmann N, Swardfager W, Yi H, Black SE, Gao FQ, Snaiderman A, Lanctôt KL

Neuropsychiatric Disease and Treatment 2014, 10:1827-1835

Published Date: 22 September 2014

Relationship between hair cortisol concentrations and depressive symptoms in patients with coronary artery disease

Yekta Dowlati, Nathan Herrmann, Walter Swardfager, et al

Neuropsychiatric Disease and Treatment 2010, 6:393-400

Published Date: 24 June 2010

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010