Back to Journals » Neuropsychiatric Disease and Treatment » Volume 13

A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms

Authors van Woerkom AE

Received 30 September 2016

Accepted for publication 3 December 2016

Published 31 January 2017 Volume 2017:13 Pages 275—302

DOI https://doi.org/10.2147/NDT.S123612

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Roger Pinder


Arthur Ernst van Woerkom

South Birmingham and Solihull Mental Health NHS Foundation Trust, Longbridge CMHT, Rubery, Birmingham, UK

Abstract: It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg++] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg++] level.

Keywords: lithium, magnesium, GSK-3, traumatic brain injury, inositol, PRPP, valproate, carbamazepine, TRPM-7

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]