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Wnt signaling pathway in retinal vascularization

Authors Drenser KA

Received 31 October 2015

Accepted for publication 18 May 2016

Published 9 August 2016 Volume 2016:8 Pages 141—146

DOI https://doi.org/10.2147/EB.S94452

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Margaret Wong-Riley


Kimberly A Drenser

Associated Retinal Consultants, Royal Oak, MI, USA

Abstract: Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.

Keywords: Wnt, norrin, angiogenesis, development, ROP, prematurity

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