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Wide Stromal Mapping Using an Anterior Segment Optical Coherence Tomography

Authors Hashmani N, Hashmani M, Asghar N, Islam M, Hashmani S

Received 12 December 2019

Accepted for publication 26 February 2020

Published 10 March 2020 Volume 2020:14 Pages 751—757


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Nauman Hashmani, Maria Hashmani, Noureen Asghar, Mahnoor Islam, Sharif Hashmani

Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan

Correspondence: Nauman Hashmani 68/B Khayaban-e-Shahbaz, DHA Phase 7, Karachi, Pakistan
Tel +92 321-2828062

Purpose: To quantify and assess the reproducibility of the corneal stromal thickness profiles captured by the SD-OCT. Secondly, we correlated the zonal thicknesses to the age, gender and axial length.
Methods: We included 227 normal eyes of 227 patients with a maximum hypermetropia of +5 and myopia of – 6 diopters (D). Subjects with an intraocular pressure exceeding 22 mm Hg, evidence of cataract formation, history of ophthalmic surgery or disease were excluded. Lastly, reproducibility was evaluated in a subset of 50 participants by means of an identical scan protocol repeated by 2 different OCT operators.
Results: Stromal values were consistently thicker in the peripheral cornea (p< 0.001). Age was negatively correlated with approximately every sector of the stroma with notable exceptions of the center (r=0.117, p=0.088) and the superior inner (r=0.057, 0.409), middle (r=0.086, p=0.209) and outer locations (r=0.120, p=0.079). There was no statistical significance in most sectors when looking at the axial length, gender and K1/K2. This method was highly reproducible in terms of both the ICC and COV.
Conclusion: Corneal stromal mapping is highly reproducible and shows a negative correlation to age. Additionally, the periphery of the stroma is consistently thicker to the center. Other variables like gender and axial length show no relationship to the corneal stroma.

Keywords: cornea, corneal stroma, OCT, AS-OCT, tomography, topography

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