Back to Journals » International Journal of Nanomedicine » Volume 10 » Issue 1

Visible-light-responsive ZnCuO nanoparticles: benign photodynamic killers of infectious protozoans

Authors Nadhman A, Nazir S, Khan MI, Ayub A, Muhammad B, Khan M, Shams DF, Yasinzai M

Received 2 July 2015

Accepted for publication 6 September 2015

Published 4 November 2015 Volume 2015:10(1) Pages 6891—6903

DOI https://doi.org/10.2147/IJN.S91666

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Marek Witold Radomski

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J Webster

Akhtar Nadhman,1,2 Samina Nazir,2 Malik Ihsanullah Khan,1 Attiya Ayub,2,3 Bakhtiar Muhammad,3 Momin Khan,1 Dilawar Farhan Shams,4 Masoom Yasinzai1,5

1Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan; 2Nanosciences and Catalysis Division, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad, Pakistan; 3Department of Chemistry, Hazara University, Dhodial, Pakistan; 4Department of Environmental Sciences, Abdul Wali Khan University Mardan, Mardan, Pakistan; 5Center of Interdisciplinary Research, International Islamic University, Islamabad, Pakistan


Abstract: Human beings suffer from several infectious agents such as viruses, bacteria, and protozoans. Recently, there has been a great interest in developing biocompatible nanostructures to deal with infectious agents. This study investigated benign ZnCuO nanostructures that were visible-light-responsive due to the resident copper in the lattice. The nanostructures were synthesized through a size-controlled hot-injection process, which was adaptable to the surface ligation processes. The nanostructures were then characterized through transmission electron microscopy, X-ray diffraction, diffused reflectance spectroscopy, Rutherford backscattering, and photoluminescence analysis to measure crystallite nature, size, luminescence, composition, and band-gap analyses. Antiprotozoal efficiency of the current nanoparticles revealed the photodynamic killing of Leishmania protozoan, thus acting as efficient metal-based photosensitizers. The crystalline nanoparticles showed good biocompatibility when tested for macrophage toxicity and in hemolysis assays. The study opens a wide avenue for using toxic material in resident nontoxic forms as an effective antiprotozoal treatment.

Keywords: zinc oxide, nanoparticles, doping, photodynamic therapy, Leishmania

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

"Smart" nickel oxide based core–shell nanoparticles for combined chemo and photodynamic cancer therapy

Bano S, Nazir S, Munir S, AlAjmi MF, Afzal M, Mazhar K

International Journal of Nanomedicine 2016, 11:3159-3166

Published Date: 12 July 2016

Readers of this article also read:

The diameter of nanotubes formed on Ti-6Al-4V alloy controls the adhesion and differentiation of Saos-2 cells

Filova E, Fojt J, Kryslova M, Moravec H, Joska L, Bacakova L

International Journal of Nanomedicine 2015, 10:7145-7163

Published Date: 20 November 2015

The effects of hierarchical micro/nanosurfaces decorated with TiO2 nanotubes on the bioactivity of titanium implants in vitro and in vivo

Ding XL, Zhou L, Wang JX, Zhao QX, Lin X, Gao Y, Li SB, Wu JY, Rong MD, Guo ZH, Lai CH, Lu HB, Jia F

International Journal of Nanomedicine 2015, 10:6955-6973

Published Date: 9 November 2015

Graphene oxide-silver nanocomposite as a promising biocidal agent against methicillin-resistant Staphylococcus aureus

de Moraes ACM, Lima BA, de Faria AF, Brocchi M, Alves OL

International Journal of Nanomedicine 2015, 10:6847-6861

Published Date: 2 November 2015

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment

Sanna V, Chamcheu JC, Pala N, Mukhtar H, Sechi M, Siddiqui IA

International Journal of Nanomedicine 2015, 10:6835-6846

Published Date: 30 October 2015

Improvement in the amine glass platform by bubbling method for a DNA microarray

Jee SH, Kim JW, Lee JH, Yoon YS

International Journal of Nanomedicine 2015, 10:273-280

Published Date: 3 October 2015

Targeting cancer stem cells by using the nanoparticles

Hong IS, Jang GB, Lee HY, Nam JS

International Journal of Nanomedicine 2015, 10:251-260

Published Date: 10 September 2015