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Utility Index and Patient-Reported Outcome Measures in Glaucomatous Patients Comparing with Normal Participants

Authors Rojananuangnit K, Sudjinda N

Received 3 January 2021

Accepted for publication 3 February 2021

Published 25 February 2021 Volume 2021:15 Pages 835—843

DOI https://doi.org/10.2147/OPTH.S300226

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Kulawan Rojananuangnit, Nuttawan Sudjinda

Glaucoma Unit, Ophthalmology Department, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, Thailand

Correspondence: Kulawan Rojananuangnit
Glaucoma Unit, Ophthalmology Department, Mettapracharak (Wat Rai Khing) Hospital, 52 Moo 2 Rai Khing District, Sampran, Nakhon Pathom, 73210, Thailand
Tel +66 34388712
Fax +66 25897296
Email [email protected]

Purpose: Utility index is a significant outcome in terms of health economics assessment while patient-reported outcome measure (PROMs) evaluates quality of life (QOL) from patient’s perspective. Our objective was to evaluate both utility indices and PROMs using generic and eye specific QOL in glaucomatous patients compared with normal population.
Methods: This is a case-control study. We interviewed normal and glaucomatous participants with the European Quality of Life questionnaire (EQ-5D-5L), the European visual analogue scale (EQ-VAS) and the visual function questionnaire 28 (Thai version) (VFQ-28). The visual function questionnaire utility index (VFQ-UI) and generic utility index from EQ-5D-5L were calculated.
Results: There were 47 normal and 127 glaucomatous participants in this study. Amongst glaucoma group, 35 participants were in the early stage of the disease, 43 were in the moderate stage, 30 normal vision participants were in the severe stage, 14 participants had blindness one eye, and 5 had blindness both eyes. The mean age of the participants in both groups was statistically similar (63.78± 6.84 vs 66.30± 8.93 years old, respectively, p=0.062). Underlying diseases between groups were also comparable. The EQ-5D-5L utility index score and the EQ-VAS score were not statistically different between normal and glaucomatous groups, respectively (EQ-5D-5L: 0.874± 0.122 vs 0.837± 0.191, p=0.215; EQ VAS: 76.06± 15.07 vs 74.02 ± 15.10, p=0.43). By contrast, VFQ-UI of the glaucomatous group was significantly lower than that of the normal group, (VFQ-UI: 0.833± 0.147 vs 0.895± 0.070, accordingly, p< 0.05).
Conclusions: Utility index from the VFQ-UI was a relevant PROMs for evaluating the QOL of glaucomatous patients in terms of visual function specificity and acceptable validity.

Keywords: quality of life in glaucomatous patients, utility index of glaucoma, patient-reported outcome measures, PROMs, the visual function questionnaire utility index in glaucoma, VFQ-UI, the European Quality of Life questionnaire in glaucoma, EQ-5D-5L, the visual function questionnaire 28 Thai-version, VFQ-28

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