Back to Journals » Clinical Interventions in Aging » Volume 7

Upper limit of the normal range for thyrotropin-stimulating hormone is higher with increasing age

Authors Jolobe O

Received 20 June 2012

Accepted for publication 26 June 2012

Published 1 August 2012 Volume 2012:7 Pages 299—301


Oscar MP Jolobe

Manchester Medical Society, Manchester, United Kingdom
The assertion that aging is associated with a decreasing concentration of thyrotropin-stimulating hormone (TSH) in healthy elderly humans1 appears to be at odds with the observation that "TSH distribution shifts towards higher concentrations with age."2 The latter conclusion was based on a study that analyzed the age-specific distribution of serum TSH in 14,376 disease-free subjects with negative thyroid antibody tests. In that study, the percentage of TSH measurements in the 2.5–4.5 mIU/L range progressively increased with age from approximately 6.5% in the 20–29-year age group to 23.9% in the 80 years and older age group. Likewise, the percentage of TSH measurements in the .4.5 mIU/L category progressively increased from 2.0% in the 20–29-year age group to 12% in the 80 years and older age group.

View original paper by Bensenor and colleagues.

Corrigendum for this letter has been published

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010