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Unresectable hepatoblastoma: current perspectives

Authors Trobaugh-Lotrario AD, Meyers RL, O'Neill AF, Feusner JH

Received 14 June 2016

Accepted for publication 22 July 2016

Published 1 February 2017 Volume 2017:9 Pages 1—6

DOI https://doi.org/10.2147/HMER.S89997

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Gerry Lake-Bakaar


Angela D Trobaugh-Lotrario,1 Rebecka L Meyers,2 Allison F O’Neill,3 James H Feusner4

1Department of Pediatric Hematology and Oncology, Providence Sacred Heart Children’s Hospital, Spokane, WA, 2Primary Children’s Hospital, University of Utah, Salt Lake City, UT, 3Dana-Farber Cancer Institute and Harvard University, Boston, MA, 4Children’s Hospital & Research Center Oakland, Oakland, CA, USA

Abstract: Although rare, hepatoblastoma is the most common pediatric liver tumor. Complete resection is a critical component for cure; however, most patients will have tumors that are not resected at diagnosis. For these patients, administration of neoadjuvant chemotherapy renders tumors resectable in most patients. For patients whose tumors remain unresectable after chemotherapy, liver transplantation is indicated (in the absence of active unresectable metastatic disease). In patients whose tumors remain unresectable after conventional chemotherapy, interventional techniques may serve as a promising option to reduce tumor size, decrease systemic toxicity, decrease need for liver transplantation, and increase feasibility of tumor resection.

Keywords: hepatoblastoma, unresectable, pediatric

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