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Treatment of myopic choroidal neovascularization with intravitreal ranibizumab injections: the role of age

Authors Karagiannis D, Kontadakis GA, Kaprinis K, Giarmoukakis A, Georgalas I, Parikakis EA, Tsilimbaris MK

Received 20 February 2017

Accepted for publication 19 April 2017

Published 22 June 2017 Volume 2017:11 Pages 1197—1201

DOI https://doi.org/10.2147/OPTH.S135174

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Dimitrios Karagiannis,1 Georgios A Kontadakis,1,2 Konstantinos Kaprinis,1 Athanassios Giarmoukakis,2 lias Georgalas,3 Efstratios A Parikakis,1 Miltiadis K Tsilimbaris2

1Ophthalmiatreio Eye Hospital of Athens, Athens, Greece; 2Department of Ophthalmology, University Hospital of Heraklion, University of Crete, Heraklio, Greece; 3Department of Ophthalmology, University of Athens, Athens, Greece

Purpose: The aim of this study was to explore the role of age as a prognostic factor for the outcome of myopic choroidal neovascularization (CNV) treatment with intravitreal ranibizumab injections.
Methods: A retrospective review of charts of patients treated with intravitreal injections of ranibizumab for the treatment of myopic CNV was done. Patients with other ophthalmic disease were excluded. Patients were followed for at least 2 years. The correlation between age and the change in visual acuity and the number of injections during treatment was investigated.
Results: Age of the patients was significantly correlated with the number of injections that the patients received (Pearson’s r=0.585, P=0.005). Also, it was significantly correlated with improvement in corrected distance visual acuity, defined as the difference between final and initial LogMAR corrected distance visual acuity (Pearson’s r=0.614, P=0.003).
Conclusion: Age significantly affects the visual outcome of myopic CNV treatment with ranibizumab. Younger patients in our study needed fewer intravitreal injections and achieved a more significant improvement in vision.

Keywords: myopic choroidal neovascularization, intravitreal injection, ranibizumab, pathologic myopia

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