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Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Authors Jasmin, Souza GT, Louzada RA, Rosado-de-Castro PH, Mendez-Otero R, Campos de Carvalho AC

Received 4 November 2016

Accepted for publication 2 December 2016

Published 25 January 2017 Volume 2017:12 Pages 779—793

DOI https://doi.org/10.2147/IJN.S126530

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lakshmi Kiran Chelluri

Peer reviewer comments 3

Editor who approved publication: Dr Thomas J. Webster


Jasmin,1,* Gustavo Torres de Souza,2,3,* Ruy Andrade Louzada,4 Paulo Henrique Rosado-de-Castro,5 Rosalia Mendez-Otero,6 Antonio Carlos Campos de Carvalho6

1NUMPEX-Bio, Federal University of Rio de Janeiro, Duque de Caxias, RJ, 2Laboratory of Animal Reproduction, Embrapa Dairy Cattle, Juiz de Fora, MG, 3Laboratory of Genetics, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil; 4Institute Gustave-Roussy of Oncology, Paris-Sud University, Villejuif, France; 5Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 6Institute Carlos Chagas Filho of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil

*These authors contributed equally to this work


Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models.

Keywords: nanoparticles, superparamagnetic iron oxide nanoparticles, stem cells, cell tracking, in vivo imaging, myocardial infarction

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