Back to Journals » Clinical Ophthalmology » Volume 13

Topometric Indices And Corneal Densitometry Change After Corneal Refractive Surgery Combined With Simultaneous Collagen Crosslinking

Authors Piyacomn Y, Kasetsuwan N, Puangsricharern V, Reinprayoon U, Satitpitakul V, Chantaren P

Received 3 August 2019

Accepted for publication 5 September 2019

Published 27 September 2019 Volume 2019:13 Pages 1927—1933


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Yonrawee Piyacomn, Ngamjit Kasetsuwan, Vilavun Puangsricharern, Usanee Reinprayoon, Vannarut Satitpitakul, Patchima Chantaren

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Correspondence: Ngamjit Kasetsuwan
Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10310, Thailand
Tel +6628-1-920-0553

Purpose: To show the alteration of tomography, topometric indices and corneal densitometry after corneal refractive surgery combined with collagen crosslinking.
Patients and methods: All medical records of patients undergoing corneal refractive surgery with simultaneous collagen crosslinking during April 2015 and August 2018 were retrospectively reviewed. Corneal tomography, higher-order aberrations (HOA), topographic indices and corneal densitometry were evaluated. All the data at 1 month, 3 months and 6 months were compared to baseline value. All complications were noted. P value less than 0.05 was considered statistically significant.
Results: Medical records of fourteen patients (twenty-five eyes) were reviewed. HOA increased at all time points (p < 0.05). Keratoconus index and central keratoconus index decreased, whereas index of surface variance, index of vertical asymmetry, index of height decentration and the minimum of radius of curvature increased at all time points (p < 0.05). Index of height asymmetry increased at 3 and 6 months (p < 0.05). Corneal densitometry at anterior layer of 0–10 mm zone and center layer of 0–6 mm zone increased at 1 and 3 months (p < 0.05). At 6 months, the densitometry at 0–6 mm zone returned to baseline level. However, at 6 months, at anterior and center layer of 6–10 mm zone, the densitometry values were still more than preoperative values (p < 0.05). There was one case of bacterial keratitis.
Conclusion: After the corneal refractive surgery combined with collagen crosslinking, the HOA and corneal densitometry increased. Topographic indices showed conflicting results.

Keywords: PRK, LASIK, SMILE, Xtra, corneal densitometry, topometric index

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]