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Topiramate-induced maculopathy in IgG4-related disease
Authors DaCosta J, Younis S
Received 6 February 2016
Accepted for publication 9 April 2016
Published 8 June 2016 Volume 2016:8 Pages 59—63
DOI https://doi.org/10.2147/DHPS.S105962
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Lucy Goodman
Peer reviewer comments 2
Editor who approved publication: Professor Rajender Aparasu
Joanna DaCosta,1,2 Saad Younis1
1Ophthalmology Department, Imperial College Healthcare NHS Trust, Western Eye Hospital, 2Barts Health NHS Trust, Whipps Cross University Hospital, London, UK
Abstract: This report describes a case of reversible topiramate-induced maculopathy in a 32-year-old female patient with IgG4-related disease. The patient presented with decreased vision associated with anterior uveitis and cystoid macula edema, which was unresponsive to oral and topical steroids. Following topiramate cessation, both cystoid macula edema and vision improved. The ocular side effects of topiramate and putative pharmacological mechanisms for topiramate-induced maculopathy in the context of IgG4-related disease are discussed. This report highlights that neurologists and ophthalmologists should be aware that patients presenting with topiramate-associated maculopathy should be advised to discontinue topiramate promptly to prevent irreversible loss of vision.
Keywords: IgG4 disease, maculopathy, topiramate
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