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Thematic Series on Clinical Cases on Haemostatic Disorders

Authors Di Micco P

Received 20 December 2019

Accepted for publication 31 December 2019

Published 30 January 2020 Volume 2020:11 Pages 33—34


Checked for plagiarism Yes

Editor who approved publication: Dr Martin H. Bluth

Pierpaolo Di Micco

Department of Medicine and Emergency Room, Fatebenefratelli Hospital of Naples, Italy

Correspondence: Pierpaolo Di Micco Email

In daily clinical practice, venous thromboembolism (VTE) may be divided into provoked VTE or unprovoked VTE as a VTE event that appears without recent contact with common thrombotic risk factors.1 This classification is relevant, because the duration of anticoagulant treatment differs in cases of provoked or unprovoked VTE. In this way, provoked VTE is a VTE event that appears in the presence of such thrombotic risk factors. Common thrombotic risk factors have been identified by international guidelines as clinical conditions that need pharmacological prophylaxis to prevent VTE (i.e., recent surgery, recent hypomobilization, pregnancy, hormonal treatment, molecular inherited/acquired thrombophilia, cancer and its therapy).2 However, using this method, nearly 40% of VTE events may be considered unprovoked or idiopathic,1 although other clinical conditions such as inflammatory bowel diseases, immunopathological diseases and other molecular defects may be associated with VTE, as hypofibrinolysis and so on.3 Acquired resistance to protein C activity, postinflammatory increase of factor VIII, and antiphoshpholipid antibodies are all conditions that may be associated with VTE.


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