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The pharmacology and therapeutic potential of (-)-huperzine A

Authors Tun MKM, Herzon S

Received 25 May 2012

Accepted for publication 14 July 2012

Published 6 September 2012 Volume 2012:4 Pages 113—123

DOI https://doi.org/10.2147/JEP.S27084

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5


Maung Kyaw Moe Tun, Seth B Herzon

Department of Chemistry, Yale University, New Haven, CT, USA

Abstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (–)-huperzine A (1). Synthetic studies of (–)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.

Keywords: Alzheimer's, NMDA, neurodegeneration, natural products, synthesis

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