Back to Journals » Clinical Interventions in Aging » Volume 8

The epidemiology of premature aging and associated comorbidities

Authors Coppedè F

Received 2 July 2013

Accepted for publication 10 July 2013

Published 5 August 2013 Volume 2013:8 Pages 1023—1032

DOI https://doi.org/10.2147/CIA.S37213

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Fabio Coppedè

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

Abstract: Hutchinson–Gilford Progeria Syndrome and Werner syndrome, also known as childhood- and adulthood-progeria, respectively, represent two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. The discovery of their genetic basis has led to the identification of several gene mutations leading to a spectrum of progeroid phenotypes ranging from moderate and mild–severe to very aggressive forms. In parallel, the creation of disease registers and databases provided available data for the design of relatively large-scale epidemiological studies, thereby allowing a better understanding of the nature and frequency of the premature aging-associated signs and symptoms. The aim of this article is to review the most recent findings concerning the epidemiology of premature aging disorders, their genetic basis, and the most recent reports on the frequency of associated diseases.

Keywords: Hutchinson–Gilford Progeria Syndrome, Werner syndrome, premature aging disorders, epidemiology, cardiovascular diseases, cancer, atherosclerosis, genetics, sign and symptoms

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