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The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin

Authors Takagi Y, Ning X, Takahashi A, Ishizaki C, Nishizaka T, Kaizu K, Miyaki M, Yamamuro H, Kawashima M

Received 29 November 2017

Accepted for publication 7 February 2018

Published 6 April 2018 Volume 2018:11 Pages 141—148


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Yutaka Takagi,1 Xuanhe Ning,1 Akihiko Takahashi,1 Chiaki Ishizaki,2 Takahiro Nishizaka,1 Kazuhiro Kaizu,1 Masahiro Miyaki,1 Hotaka Yamamuro,1 Makoto Kawashima3

1Skin Care Product Research, Kao Corporation, Tokyo, Japan; 2Ebisu Skin Research Center, Inforward, Inc., Tokyo, Japan; 3Department of Dermatology, Tokyo Women’s Medical University, Tokyo, Japan

Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.
Methods: Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.
Results: Skin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16®.
Conclusion: From these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.

Keywords: formulation, skin care, moisturization, scalp lotion, sensitive skin, inflammation

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