Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Synergetic effect of functional cadmium–tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition

Authors Xu P, Li J, Shi L, Selke M, Chen B, Wang X

Received 16 July 2013

Accepted for publication 21 August 2013

Published 30 September 2013 Volume 2013:8(1) Pages 3729—3736

DOI https://doi.org/10.2147/IJN.S51622

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Peipei Xu,1 Jingyuan Li,2 Lixin Shi,3 Matthias Selke,3 Baoan Chen,4 Xuemei Wang5
1Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Laboratory Animal Center, Institute of Comparative Medicine, Nantong University, Nantong, People’s Republic of China; 3Department of Chemistry and Biochemistry, California State University – Los Angeles, Los Angeles, CA, USA; 4Department of Hematology, Zhongda Hospital, Southeast University, Nanjing, People’s Republic of China; 5State Key Lab of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, People’s Republic of China

Abstract: We prepared and studied novel fluorescent nanocomposites based on gambogic acid (GA) and cadmium–tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined treatment. The nanocomposites were denoted as GA-CdTe. Characterization results indicated that the CdTe QDs can readily bind onto cell plasma membranes and then be internalized into cancer cells for real-time labeling and tracing of human liver hepatocellular carcinoma cell line (HepG2) cells. GA-CdTe significantly enhanced drug accumulation in HepG2 cells and inhibited cancer cell proliferation. GA-CdTe nanocomposites also improved the drug action of GA molecules in HepG2 cells and induced the G2/M phase arrest of the cancer cell cycle, promoting cell apoptosis. Given the sensitive, pH-triggered release of GA-CdTe, the side effects of GA anticancer agents on normal cells/tissues in the blood circulation markedly decreased. Efficient drug release and accumulation in target tumor cells were also facilitated. Thus, the fluorescent GA-CdTe offered a new strategy for potential multimode cancer therapy and provided new channels for research into naturally-active compounds extracted from traditional Chinese medicinal plants.

Keywords:
cadmium-tellurium quantum dots, gambogic acid, drug delivery, cell labeling, therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles

Vandooren J, Berghmans N, Dillen C, Van Aelst I, Ronsse I, Israel LL, Rosenberger I, Kreuter J, Lellouche JP, Michaeli S, Locatelli E, Comes Franchini M, Aiertza MK, Sánchez-Abella L, Loinaz I, Edwards DR, Shenkman L, Opdenakker G

International Journal of Nanomedicine 2013, 8:4745-4756

Published Date: 13 December 2013

Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer

Lee HY, Mohammed KA, Kaye F, Sharma P, Moudgil BM, Clapp WL, Nasreen N

International Journal of Nanomedicine 2013, 8:4481-4494

Published Date: 21 November 2013

Synthesis, characterization, and evaluation of paclitaxel loaded in six-arm star-shaped poly(lactic-co-glycolic acid)

Chen Y, Yang Z, Liu C, Wang C, Zhao S, Yang J, Sun H, Zhang Z, Kong D, Song C

International Journal of Nanomedicine 2013, 8:4315-4326

Published Date: 7 November 2013

Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

Kalmodia S, Harjwani J, Rajeswari R, Yang W, Barrow CJ, Ramaprabhu S, Krishnakumar S, Elchuri SV

International Journal of Nanomedicine 2013, 8:4327-4338

Published Date: 6 November 2013

Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia

de Sousa VP, Crean J, Borges VRA, Rodrigues CR, Tajber L, Boylan F, Cabral LM

International Journal of Nanomedicine 2013, 8:3129-3139

Published Date: 15 August 2013

Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy

Li C, Zhang X, Huang X, Wang X, Liao G, Chen Z

International Journal of Nanomedicine 2013, 8:1285-1292

Published Date: 24 March 2013