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Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Authors Liu K, Liu P, Liu R, Wu X, Cai M, Xia K

Received 25 November 2014

Accepted for publication 23 December 2014

Published 30 January 2015 Volume 2015:9 Pages 707—716

DOI https://doi.org/10.2147/DDDT.S78070

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Shu-Feng Zhou


Kuan Liu,* Pengcheng Liu,* Run Liu, Xing Wu, Ming Cai

Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Purpose: To investigate the effectiveness and safety of epidural steroid injections in patients with lumbar spinal stenosis (LSS).
Methods: We performed a search on the CENTRAL, Pubmed, Embase and Cochrane databases up to September 2014. We recovered 17 original articles, of which only 10 were in full compliance with the randomized controlled trial (RCT) criteria. These articles were reviewed in an independent and blinded way by two reviewers who were previously trained to extract data and score their quality by the criteria of the Cochrane Handbook (5.1.0).
Results: We accepted ten studies with 1,010 participants. There is minimal evidence that shows that epidural steroid injections are better than lidocaine alone, regardless of the mode of epidural injection. There is a fair short-term and long-term benefit for treating spinal stenosis with local anesthetic and steroids.
Conclusions: This meta-analysis suggests that epidural steroid injections provide limited improvement in short-term and long-term benefits in LSS patients.

Keywords: lumbar spinal stenosis, epidural injection, steroid, local anesthetic, chronic pain

A Letter to the Editor has been received and published for this article


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