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Spotlight on reticular pseudodrusen

Authors Rabiolo A, Sacconi R, Cicinelli MV, Querques L, Bandello F, Querques G

Received 21 July 2017

Accepted for publication 28 August 2017

Published 20 September 2017 Volume 2017:11 Pages 1707—1718

DOI https://doi.org/10.2147/OPTH.S130165

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Alessandro Rabiolo,1 Riccardo Sacconi,1,2 Maria Vittoria Cicinelli,1 Lea Querques,1,3 Francesco Bandello,1 Giuseppe Querques1

1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 2Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, 3G. B. Bietti Foundation-IRCCS, Rome, Italy

Abstract: Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch’s membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD. RPD identification is not straightforward at fundus examination, and their identification should employ at least 2 different imaging modalities. In this narrative review, we embrace all aspects of RPD, including history, epidemiology, histology, imaging, functional test, natural history and therapy.

Keywords: age-related macular degeneration, choroidal neovascularization, geographic atrophy, reticular macular degeneration, reticular drusen, reticular macular disease, reticular pseudodrusen, subretinal drusenoid deposit

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