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Spotlight on fundus autofluorescence

Authors Calvo-Maroto AM, Cerviño A

Received 25 October 2017

Accepted for publication 17 January 2018

Published 27 March 2018 Volume 2018:10 Pages 25—32

DOI https://doi.org/10.2147/OPTO.S134637

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Mr Simon Berry


Ana M Calvo-Maroto,1 Alejandro Cerviño2

1Department of Ophthalmology, Clínica Universidad de Navarra, University of Navarra, Madrid, Spain; 2Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain

Abstract: Fundus autofluorescence (FAF) imaging is based on the fluorescence from ocular endogenous fluorophores located in the retinal pigment epithelium and choroid, mainly lipofuscin and melanin. It is a noninvasive technique that provides information about the spatial distribution of lipofuscin/melanin and retinal pigment epithelium health status. An overview about the fluorophores responsible for FAF imaging and the usefulness of FAF imaging in the noninvasive assessment and monitoring of retinal diseases, such as age-related macular degeneration, diabetic retinopathy, diabetic macular edema, central serous chorioretinopthy, retinitis pigmentosa and retinal dystrophies, are discussed in this review.

Keywords: fundus autofluorescence, short-wavelength fundus autofluorescence, near-infrared fundus autofluorescence, lipofuscin, melanin

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