Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 9

Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Authors Aldag C, Nogueira Teixeira D, Leventhal PS

Received 30 June 2016

Accepted for publication 7 October 2016

Published 9 November 2016 Volume 2016:9 Pages 411—419

DOI https://doi.org/10.2147/CCID.S116158

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg


Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2

1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France

*These authors contributed equally to this work

Abstract:
Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation.

Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]