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Sjögren’s syndrome is associated with negatively variable impacts on domains of health-related quality of life: evidence from Short Form 36 questionnaire and a meta-analysis

Authors Zhang Q, Wang X, Chen H, Shen B

Received 19 January 2017

Accepted for publication 13 April 2017

Published 10 May 2017 Volume 2017:11 Pages 905—911

DOI https://doi.org/10.2147/PPA.S132751

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Naifeng Liu

Qiuxiang Zhang,1,2 Xulin Wang,3 Haoyang Chen,1,2 Biyu Shen1

1Department of Nursing, The Second Affiliated Hospital of Nantong University, 2School of Nursing, Nantong University, 3Department of Epidemiology and Medical Statistics, Nantong University, Nantong, Jiangsu, People’s Republic of China


Purpose: The purpose of this article was to systematically review the literature to identify the impact of primary Sjögren’s syndrome (pSS) on specific health-related quality of life (HRQoL) domains.
Methods: A meta-analysis was performed, and the related articles were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine, and Web of Science databases and in reference lists of articles and systematic reviews. Score of the Short Form 36 (SF-36) questionnaire was used as the outcome measurement, and mean differences (MD) with 95% confidence intervals (CIs) were calculated.
Results: Seven studies were included, comprising 521 patients with pSS and 9,916 healthy controls. The SF-36 questionnaire score of each domain (physical function, role physical [RP] function, emotional role function, vitality, mental health, social function, body pain, general health, physical component scale, mental component scale) was lower in patients with pSS than in healthy controls, especially the score in the dimension of RP function.
Conclusion: This meta-analysis showed that patients had lower pSS score in each dimension of the SF-36, mostly in the RP function. This demonstrated that targeted interventions should be carried out to improve the HRQoL of pSS patients.

Keywords: primary Sjögren’s syndrome, quality of life, SF-36, meta-analysis

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