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Serum total IgG and IgG4 levels in thyroid eye disease

Authors Sy A, Silkiss RZ

Received 3 July 2016

Accepted for publication 22 August 2016

Published 20 October 2016 Volume 2016:9 Pages 325—328

DOI https://doi.org/10.2147/IMCRJ.S116331

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Aileen Sy, Rona Z Silkiss

Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA

Purpose: To investigate the relationship between immunoglobulin G (IgG)4-related disease (IgG4-RD) and thyroid eye disease (TED) with respect to IgG levels.
Patients and methods: A retrospective review of total IgG, IgG subclass, and thyroid stimulating immunoglobulin (TSI) levels in 24 patients with TED.
Results: Five patients (20.8%) demonstrated serum IgG4 levels consistent with IgG4-RD without any additional systemic disease. Total IgG and IgG subclass levels were found to be an inadequate proxy for TSI elevation.
Conclusion: There may be a subtype of TED patients with elevated IgG4 in the absence of IgG4-RD systemic findings.

Keywords: thyroid eye disease, IgG subclass, IgG4, Graves’ disease, Graves’ ophthalmopathy, IgG4-RD

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