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Secondary pigmentary glaucoma in patients with underlying primary pigment dispersion syndrome

Authors Sivaraman KR, Patel CG, Vajaranant TS, Aref AA

Received 7 January 2013

Accepted for publication 29 January 2013

Published 21 March 2013 Volume 2013:7 Pages 561—566


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Kavitha R Sivaraman, Chirag G Patel, Thasarat S Vajaranant, Ahmad A Aref

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL, USA

Abstract: Primary pigment dispersion syndrome (PPDS) is a bilateral condition that occurs in anatomically predisposed individuals. PPDS may evolve into pigmentary glaucoma, but it is difficult to predict which patients will progress. Secondary pigment dispersion is more often unilateral and acquired as a result of surgery, trauma, or intraocular tumor, but can likewise lead to pigmentary glaucoma. We report two cases of patients with bilateral PPDS who developed secondary pigment dispersion and pigmentary glaucoma in one eye. Patients with PPDS who acquire a secondary mechanism of pigment dispersion may be at an increased risk of progression to pigmentary glaucoma, presumably due to an increased burden of liberated pigment. In addition to regular surveillance for progression to glaucoma from PPDS, secondary causes of pigmentary dispersion in these eyes should be considered when patients present with grossly asymmetric findings. When secondary pigment dispersion is identified in eyes with PPDS, we recommend prompt intervention to alleviate the cause of secondary pigment dispersion and/or aggressive control of intraocular pressure to limit glaucomatous damage.

Keywords: primary pigment dispersion syndrome, pigmentary glaucoma

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