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Role of Helicobacter pylori Eradication in Chronic Spontaneous Urticaria: A Propensity Score Matching Analysis

Authors Guo Y, Li HM, Zhu WQ, Li Z

Received 24 November 2020

Accepted for publication 26 December 2020

Published 5 February 2021 Volume 2021:14 Pages 129—136

DOI https://doi.org/10.2147/CCID.S293737

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Yan Guo, Hua-Ming Li, Wei-Qin Zhu, Zhen Li

Department of Gastroenterology, Hangzhou Third People’s Hospital, Hangzhou, 310009, People’s Republic of China

Correspondence: Yan Guo
Department of Gastroenterology Hangzhou Third People’s Hospital, No. 38 West Lake Road, Shangcheng District, Hangzhou, 310009, People’s Republic of China
Tel +86 571 87823158
Fax +86 571 87814481
Email yanguodr1@163.com

Objective: To investigate the role of Helicobacter pylori (HP) eradication in chronic spontaneous urticaria (CSU) treatment.
Methods: Retrospective analysis was performed on the clinical data of 522 patients with CSU who underwent a HP breath test in Hangzhou Third People’s Hospital between January 2018 and December 2019. The CSU-HP(+) group consisted of patients with CSU and HP infection, who were treated with antihistamines combined with HP eradication therapy. The CSU-HP(-) group consisted of patients with CSU alone, who were treated with antihistamines. Propensity score matching (PSM) analysis, using the nearest neighbor matching method on a 1:1 basis, was performed to ensure the characteristics of the CSU-HP(+) and CSU-HP(-) groups were similar. Factors, including age, gender, white blood cells, red blood cells, platelets, alanine transaminase, creatinine, immunoglobulin E, and pre-treatment urticaria activity score (UAS), were matched to obtain a balanced cohort of patients in each group. Therapeutic effects were compared after matching. t-tests, &KHgr;2 test, and McNemar’s test were used for comparison between the two groups before and after matching.
Results: Patients in the CSU-HP(+) group reported significantly more gastrointestinal symptoms than those in the CSU-HP(-) group. UAS scores in the second week of treatment were significantly different between the two groups. After 3 months, the recurrence rate in the CSU-HP(+) group was lower than in the CSU-HP(-) group.
Conclusion: Eradication of HP infection in patients with CSU helps relieve gastrointestinal symptoms, improves the therapeutic effect of CSU within 2 weeks, and reduces the recurrence rate 3 months after treatment.

Keywords: chronic urticaria, chronic spontaneous urticaria, Helicobacter pylori, eradication therapy

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