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Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

Authors Ganesan P, Ramalingam P, Karthivashan G, Ko YT, Choi DK

Received 30 October 2017

Accepted for publication 15 December 2017

Published 15 March 2018 Volume 2018:13 Pages 1569—1583

DOI https://doi.org/10.2147/IJN.S155593

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Palanivel Ganesan,1,2,* Prakash Ramalingam,3,4,* Govindarajan Karthivashan,1,* Young Tag Ko,4 Dong-Kug Choi1,2

1Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 2Nanotechnology Research Center and Department of Applied Life Science, Konkuk University, Chungju, Republic of Korea; 3Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences, Philadelphia, PA, USA; 4College of Pharmacy, Gachon University, Incheon, Republic of Korea

*These authors contributed equally to this work

Abstract: Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through oral delivery. However, the burst release makes the SLN delivery systems inadequate for the oral delivery of various phyto-bioactive compounds that can treat such chronic diseases. Recently, the surface-modified SLN (SMSLN) was observed to overcome this limitation for oral delivery of phyto-bioactive compounds, and there is growing evidence of an enhanced uptake of curcumin delivered orally via SMSLNs in the brain. This review focuses on different SLN and SMSLN systems that are useful for oral delivery of phyto-bioactive compounds to treat various chronic diseases.

Keywords: solid lipid nanoparticles, surface-modified solid lipid nanoparticles, chronic diseases, phyto-bioactive compounds, chitosan

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