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Recent advances in green fluorine chemistry

Authors Zeng Y, Hu J

Received 1 January 2015

Accepted for publication 28 January 2015

Published 14 May 2015 Volume 2015:5 Pages 19—39

DOI https://doi.org/10.2147/ROC.S80171

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Sean Kerwin


Yuwen Zeng, Jinbo Hu

Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, People’s Republic of China

Abstract: Fluorinated compounds are intriguing for the development of pharmaceuticals, agrochemicals, and materials, and thus, much effort has been exerted to develop more general and efficient approaches for introducing fluorine atom(s) or fluoroalkyl group(s) into organic molecules. Although many traditional methods usually cannot satisfy the simplicity and cost efficiency for industrial production and laboratorial synthesis, significant progress in green fluorine chemistry has been made in recent years, allowing efficient incorporation of fluorine into complex organic molecules. The main purpose of this review is to describe recent advances in organofluorine chemistry, with an emphasis on generality, selectivity, and environmental friendliness of related methods.

Keywords: green chemistry, organofluorine chemistry, fluorination, perfluoroalkylation, trifluoromethylation

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