Dr Federico Perche
Consulting Editor: Federico Perche (PhD)
Postdoctoral Research Associate, Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Japan
During his PhD at the Center for Molecular Biophysics (Orléans, France) with Dr. Midoux and Dr. Pichon, Federico Perche developed dendritic cell-targeted lipopolyplexes, achieving efficient transfection of splenic dendritic cells in vivo resulting in superior protection against melanoma growth over untargeted mRNA lipopolyplexes. Next he did a postdoctoral stay with Pr. Torchilin at the Center for Pharmaceutical Biotechnology and Nanomedicine (Northeastern University, Boston, USA). There he worked on stimuli-sensitive delivery systems for siRNA and drug (paclitaxel and doxorubicin) delivery. With his colleagues, they demonstrated triggered exposure of internalization motifs by two tumor environment stimuli: matrix metalloproteases, and hypoxia. He continued his training in Pharmaceutical Sciences by a second postdoctoral stay as Japanese Society for the Promotion of Science fellow with Pr. Kataoka at the Center for Nano Bio Integration (The University of Tokyo, Japan). He currently works on improved targeting of siRNA formulations.