Dr Mafalda Cacciottolo
Consulting Editor: Mafalda Cacciottolo (PhD)
Postdoctoral Research Associate, USC Leonard Davis School of Gerontology, University of Southern California, Los Angeles, USA
Dr Mafalda Cacciottolo gained her PhD in Medical Generics in 2009 at Seconda Universita' degli Studi in Naples (Italy). She worked on the molecular and genetic aspects of Limb Girdle Muscualr Dystrophy Type 2B, as known as dysferlinopathy (Cacciottolo et al, Eur J Hum Genet. 2011, Cacciottolo et al, JBC 2011). She joined the University of Southern California for her postdoctoral training in 2011. As a Postdoctoral Research Associate at the USC Neuromuscular Center in Dr Valerie Askanas’ Lab, Dr Cacciottolo worked on Sporadic Inclusion Body Myositis Disease, which shares several pathological hallmarks with AD. She gained expertise in both molecular and histological analysis of APP protein and its proteolytic peptides. She showed the interaction between Abeta and the muscular protein dysferlin by both immunoblot and immunostaining (Cacciottolo et al. Acta Neuropath 2013) and a new association between alteration of Chaperone Mediated Autophagy and sBM (Cacciottolo et al Neuropath and Applied Neurobiol 2013). She developed interest in the AD field and aging that I was able to cultivate at USC Gerontology. As Postdoc for Prof. Caleb E. Finch, she is in charge of the experimental evaluation of the causative effect between exposure to urban air pollution and AD progression using both in vivo exposure of EFAD mice and in vitro nPM treatment of N2A-APP/swe cells. She is developed interest in sex difference and development of AD. In 2014, she was awarded of the 2014 Alzheimer’s Association, California Southland Chapter Young Investigator Award. She currently works at USC Davis School of Gerontolgy as Postdoctoral Research Associate.