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Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review

Authors Copeland J, Pokorski I

Received 7 December 2015

Accepted for publication 10 February 2016

Published 3 May 2016 Volume 2016:7 Pages 41—53


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Li-Tzy Wu

Video abstract presented by Izabella Pokorski.

Views: 221

Jan Copeland, Izabella Pokorski

UNSW Medicine, University of New South Wales, Sydney, NSW, Australia

Abstract: Cannabis is the most widely used and variably regulated drug in the world, with increasing trends of use being reported in the US, Australia, Asia, and Africa. Evidence has shown a decrease in the age of commencement of cannabis use in some developed countries and a prolongation of risk of initiation to cannabis use beyond adolescence among more recent users. Cannabis use is associated with numerous health risks and long-term morbidity, as well as risk of developing cannabis-use disorders. Cannabis users infrequently seek professional treatment, and normally do so after a decade of use. Cannabis-use disorders are currently treated using a selection of psychosocial interventions. Severity of withdrawal is a factor that increases the risk of relapse, and is the target of pharmacotherapy studies. Currently, there is no approved pharmacotherapy for cannabis-use disorders. A number of approaches have been examined, and trials are continuing to find a safe and effective medication with little abuse liability.

Keywords: marijuana, treatment, intervention, withdrawal, cannabinoid

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