Back to Journals » Therapeutics and Clinical Risk Management » Volume 16

Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial

Authors Wang J, Duan J, Wang Q, Lu Y

Received 28 January 2020

Accepted for publication 27 March 2020

Published 14 April 2020 Volume 2020:16 Pages 281—286

DOI https://doi.org/10.2147/TCRM.S247437

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang


Jiang Wang,1,* Jinjuan Duan,1,2,* Qiuyue Wang,1 Yao Lu1

1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China; 2Department of Anesthesiology, Affiliated Anqing Hospital of Anhui Medical University, Anqing 246003, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yao Lu
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University Tel +86 55162922057
Email luyao-mz@163.com

Background: Sufentanil-induced cough is frequent during the induction of anesthesia. The aim of this research was to assess the influence of pretreatment with nalbuphine on sufentanil-induced cough.
Patients and Methods: A total of  210 American Society of Anesthesiologists (ASA) I–II patients who are 18– 70 years old and scheduled for elective surgery were randomly divided into two groups. Group N was pretreated with 0.3 mg/kg nalbuphine at 150 s before induction with sufentanil, and Group C received the same volume of normal saline as the placebo. We assessed the incidence and severity of cough 2 minutes after sufentanil administration. We also recorded the hemodynamic changes and side effects of sufentanil after sufentanil administration.
Results: No patients had cough in group N, and 30 patients had cough in group C (degree of cough: mild 8; moderate 10; severe 12). The incidence and severity of cough in group N were significantly lower than those in group C.
Conclusion: Pretreatment with 0.3 mg/kg nalbuphine significantly suppressed the incidence and intensity of sufentanil-induced cough.

Keywords: nalbuphine, sufentanil, cough, anesthesia

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]