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Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial

Authors Wang J, Duan J, Wang Q, Lu Y

Received 28 January 2020

Accepted for publication 27 March 2020

Published 14 April 2020 Volume 2020:16 Pages 281—286


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang

Jiang Wang,1,* Jinjuan Duan,1,2,* Qiuyue Wang,1 Yao Lu1

1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China; 2Department of Anesthesiology, Affiliated Anqing Hospital of Anhui Medical University, Anqing 246003, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yao Lu
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University Tel +86 55162922057

Background: Sufentanil-induced cough is frequent during the induction of anesthesia. The aim of this research was to assess the influence of pretreatment with nalbuphine on sufentanil-induced cough.
Patients and Methods: A total of  210 American Society of Anesthesiologists (ASA) I–II patients who are 18– 70 years old and scheduled for elective surgery were randomly divided into two groups. Group N was pretreated with 0.3 mg/kg nalbuphine at 150 s before induction with sufentanil, and Group C received the same volume of normal saline as the placebo. We assessed the incidence and severity of cough 2 minutes after sufentanil administration. We also recorded the hemodynamic changes and side effects of sufentanil after sufentanil administration.
Results: No patients had cough in group N, and 30 patients had cough in group C (degree of cough: mild 8; moderate 10; severe 12). The incidence and severity of cough in group N were significantly lower than those in group C.
Conclusion: Pretreatment with 0.3 mg/kg nalbuphine significantly suppressed the incidence and intensity of sufentanil-induced cough.

Keywords: nalbuphine, sufentanil, cough, anesthesia

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