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Photodynamic therapy for polypoidal choroidal vasculopathy secondary to choroidal nevus

Authors Wong JG, Lai XJ, Sarafian RY, Wong HS, Smith JB

Received 3 March 2016

Accepted for publication 31 March 2016

Published 14 February 2017 Volume 2017:10 Pages 51—54

DOI https://doi.org/10.2147/IMCRJ.S107648

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


James G Wong,1–3 Xin Jie Lai,1 Richard Y Sarafian,4 Hon Seng Wong,5 Jeremy B Smith6

1Strathfield Retina Clinic, Sydney, NSW, Australia; 2Medical Retina Unit, Sydney Eye Hospital, Sydney, NSW, Australia; 3Save Sight Institute, University of Sydney, Sydney, NSW, Australia; 4School of Medicine, University of Queensland, Brisbane, QLD, Australia; 5Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; 6Ophthalmology Clinic, Children’s Hospital Westmead, Sydney, NSW, Australia


Abstract: We report a case of a Caucasian female who developed active polypoidal choroidal vasculopathy (PCV) at the edge of a stable choroidal nevus and was successfully treated with verteporfin photodynamic therapy. No active polyp was detectable on indocyanine green angiography 2 years after treatment, and good vision was maintained. Indocyanine green angiography is a useful investigation to diagnose PCV and may be underutilized. Unlike treatment of choroidal neovascularization secondary to choroidal nevus, management of PCV secondary to nevus may not require intravitreal anti-vascular endothelial growth factor therapy. Photodynamic monotherapy may be an effective treatment of secondary PCV.

Keywords: chorioretinopathy, indocyanine green angiography, optical coherence tomography, OCT, fluorescein angiography, pigment epithelium detachments, PEDs, subretinal fluid

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