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Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges

Authors Haga SB

Received 11 June 2019

Accepted for publication 12 September 2019

Published 14 October 2019 Volume 2019:12 Pages 273—285

DOI https://doi.org/10.2147/PGPM.S179172

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 3

Editor who approved publication: Dr Martin H. Bluth


Susanne B Haga

Department of Medicine, Division of General Internal Medicine, Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, 27708, USA

Correspondence: Susanne B Haga
Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, 304 Research Drive, Box 90141, Durham, NC 27708, USA
Email susanne.haga@duke.edu

Abstract: For the past several years, the implementation of pharmacogenetic (PGx) testing has become widespread in several centers and clinical practice settings. PGx testing may be ordered at the point-of-care when treatment is needed or in advance of treatment for future use. The potential benefits of PGx testing are not limited to adult patients, as children are increasingly using medications more often and at earlier ages. This review provides some background on the use of PGx testing in children as well as mothers (prenatally and post-natally) and discusses the challenges, benefits, and the ethical, legal, and social implications of providing PGx testing to children.

Keywords: pharmacogenetic testing, education, benefit, risk, consent, children, maternal health

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