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Personalized skincare: from molecular basis to clinical and commercial applications

Authors Markiewicz E, Idowu OC

Received 25 January 2018

Accepted for publication 26 February 2018

Published 11 April 2018 Volume 2018:11 Pages 161—171

DOI https://doi.org/10.2147/CCID.S163799

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg


Ewa Markiewicz, Olusola Clement Idowu

Research & Development, Hexis Lab, Science Central, The Core, Bath Lane, Newcastle upon Tyne, UK

Abstract: Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects. The unique characteristics of the individual skin function and, particularly, of the ethnic skin type are currently considered to shape the future of clinical and pharmacologic interventions as a basis for personalized skincare. Individual approaches to skincare render a novel and actively growing area with a range of biomedical and commercial applications within cosmetics industry. In this review, we summarize the aspects of the molecular and clinical manifestations of the environmental stress on human skin and proposed protective mechanisms that are linked to ethnic differences and pathophysiology of extrinsic skin aging. We subsequently discuss the possible applications and translation of this knowledge into personalized skincare.

Keywords: pigmentation, gene polymorphism, photodamage, environmental stress, cosmetics

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