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PD-1 immune checkpoint blockade may be viable for the prevention and treatment of elderly patients with POCD [Letter]

Authors Wei P, Yang F, Li J

Received 12 December 2018

Accepted for publication 17 March 2019

Published 17 April 2019 Volume 2019:14 Pages 689—691

DOI https://doi.org/10.2147/CIA.S197925

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 4

Editor who approved publication: Dr Zhi-Ying Wu


Penghui Wei, Fan Yang, Jianjun Li

Department of Anesthesiology, Qilu Hospital of Shandong University (Qingdao), Qingdao 266035, People’s Republic of China

Dear Editor
Recently, we read with great interest the well-written review article published in the November 8, 2018 edition of the Clinical Interventions in Aging by Kotekar and colleagues titled “Postoperative cognitive dysfunction – current preventive strategies”.1 The article elegantly addressed the current preventive strategies for postoperative cognitive dysfunction (POCD). The authors concluded that the best preventive strategies for POCD may involve early recognition and management of potential perioperative risk factors, such as intraoperative anesthetic monitoring of the depth of anesthesia, Enhanced Recovery After Surgery and a multidisciplinary collaboration. Furthermore, the authors proposed that pharmacological interventions may be effective preventative and therapeutic strategies to attenuate POCD.We appreciate the efforts of the authors and would like to present our opinion on the review.

View the original paper by Kotekar and colleagues

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